Zysset T, Wietholtz H
Department of Pharmacy, Regionalspital Biel, Switzerland.
Eur J Clin Pharmacol. 1991;41(5):449-52. doi: 10.1007/BF00626367.
Diabetes may alter the pharmacokinetics of aminopyrine and antipyrine, which are used to assess liver function. Caffeine has recently been used to test liver function, but the effect of diabetes on caffeine kinetics is not known. The kinetics of caffeine has been examined in patients with decompensated Type I and Type II diabetes and in two age- and sex-matched control groups. In both types of diabetes the apparent caffeine clearance, half-life, and apparent volume of distribution were similar to controls. It is concluded that decompensated diabetes does not influence the cytochrome P-448 mono-oxygenase system responsible for caffeine metabolism.
糖尿病可能会改变用于评估肝功能的氨基比林和安替比林的药代动力学。咖啡因最近已被用于测试肝功能，但糖尿病对咖啡因动力学的影响尚不清楚。已对失代偿性I型和II型糖尿病患者以及两个年龄和性别匹配的对照组进行了咖啡因动力学研究。在两种类型的糖尿病中，咖啡因的表观清除率、半衰期和表观分布容积与对照组相似。结论是，失代偿性糖尿病不会影响负责咖啡因代谢的细胞色素P-448单加氧酶系统。
