1 Department of Psychiatry, National Taiwan University Hospital, Yun-Lin Branch, Yunlin.
2 Department of Psychiatry, National Taiwan University Hospital, Taipei.
Clin EEG Neurosci. 2019 Jul;50(4):227-230. doi: 10.1177/1550059419830562. Epub 2019 Mar 12.
Building on the knowledge of sex differences in auditory sensory gating in schizophrenia and hippocampal involvement in sensory gating, this study aimed to investigate sex as a potential moderator of the association between hippocampal volume and P50 in schizophrenia. Auditory P50 gating and hippocampal volume were measured in 16 male and 15 female patients with schizophrenia. The correlations between hippocampal volume and P50 were analyzed in males and females separately, corrected for potential confounders, including age, duration of illness, and antipsychotic medication. Different associative patterns of hippocampal volume with P50 gating ratio and with P50 difference were found by sex. The results suggest sex may play a role in the physiology of sensory gating.
基于听觉感觉门控中精神分裂症的性别差异以及海马在感觉门控中的参与的知识，本研究旨在探究性别是否是精神分裂症中海马体积与 P50 之间关联的潜在调节因素。在 16 名男性和 15 名女性精神分裂症患者中测量了听觉 P50 门控和海马体积。分别对男性和女性进行了校正潜在混杂因素（包括年龄、病程和抗精神病药物）后，海马体积与 P50 的相关性进行了分析。通过性别发现了海马体积与 P50 门控比值和 P50 差值之间不同的关联模式。结果表明，性别可能在感觉门控的生理学中起作用。
