Zhu Xiao Lin, Tan Shu Ping, Wang Zhi Ren, Zhang Jin Guo, Li Dong, Fan Feng Mei, Zhao Yan Li, Zou Yi Zhuang, Tan Yun Long, Yang Fu De, Zhang Xiang Yang
Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, Beijing 100096, China.
Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, Beijing 100096, China.
Neurosci Lett. 2017 Jul 13;653:346-350. doi: 10.1016/j.neulet.2017.06.009. Epub 2017 Jun 9.
Numerous studies have reported P50 gating deficits in schizophrenia, though with mixed results. Moreover, few studies have explored the association between P50 gating deficits and psychopathology in Chinese patients with schizophrenia. In the present study, we investigated the P50 auditory sensory gating patterns and their correlations with clinical symptoms in a large sample of Han Chinese patients with schizophrenia.
We assessed P50 sensory gating with a 64-channel electroencephalography system in 133 patients with schizophrenia and 148 healthy controls. The schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS).
Patients with schizophrenia had a significantly higher P50 gating ratio (p<0.001), longer S1 latency (p<0.05), lower S1 amplitude (p<0.01), and lower P50 difference (p<0.001) than did controls. No significant correlations were found between the P50 gating measures and the PANSS total score or subscale scores in patients with schizophrenia.
These findings suggest that the P50 sensory gating deficits identified in Chinese patients with schizophrenia may not be involved in the psychopathology of the illness.
众多研究报告了精神分裂症患者存在P50门控缺陷，尽管结果不一。此外，很少有研究探讨中国精神分裂症患者中P50门控缺陷与精神病理学之间的关联。在本研究中，我们调查了大量汉族精神分裂症患者的P50听觉感觉门控模式及其与临床症状的相关性。
我们使用64导脑电图系统评估了133例精神分裂症患者和148名健康对照者的P50感觉门控。采用阳性和阴性症状量表（PANSS）评估精神分裂症症状。
与对照组相比，精神分裂症患者的P50门控比率显著更高（p<0.001），S1潜伏期更长（p<0.05），S1波幅更低（p<0.01），P50差值更低（p<0.001）。在精神分裂症患者中，未发现P50门控指标与PANSS总分或各分量表得分之间存在显著相关性。
这些发现表明，在中国精神分裂症患者中发现的P50感觉门控缺陷可能与该疾病的精神病理学无关。
