a Discipline of Physiology, Adelaide Medical School , The University of Adelaide , Adelaide , South Australia.
b Department of Gastroenterology , Women's and Children's Hospital , North Adelaide , South Australia.
Nutr Cancer. 2019;71(2):199-206. doi: 10.1080/01635581.2019.1578391. Epub 2019 Mar 12.
Ulcerative colitis is an unremitting and lifelong inflammatory bowel disease that is increasing in prevalence worldwide. Patients display various clinical symptoms such as abdominal pain, diarrhea and fatigue. The etiology of ulcerative colitis remains unknown and the current pharmaceutical treatments are variably effective and not curative, highlighting the need for improved therapeutic approaches. Furthermore, patients with ulcerative colitis are at an increased risk of developing colorectal cancer. Some naturally sourced agents, named nutraceuticals, have been identified to possess anti-inflammatory and antioxidant properties. Of particular interest is Emu Oil, grape seed extract and Japanese Kampo medicine. Previously, Emu Oil has protected and repaired intestinal damage in models of gastrointestinal diseases including colitis and colitis-associated colorectal cancer. Additionally, grape seed extract possesses anticancer properties in vitro. Moreover, Kampo medicine, composed of herbal ingredients, is widely used in Japan for the treatment of various medical conditions and has demonstrated efficacy in targeting cancer cells in vitro. Nutraceuticals in combination have not yet been widely investigated in a setting of colitis-associated colorectal cancer. Investigation into the efficacy of Emu Oil combined with other nutraceuticals, including grape seed extract and Kampo medicine, is warranted as they may provide a novel approach to conventional colitis and colorectal cancer management.
溃疡性结肠炎是一种持续存在且终生存在的炎症性肠病，在全球范围内的发病率正在上升。患者表现出各种临床症状，如腹痛、腹泻和疲劳。溃疡性结肠炎的病因仍不清楚，目前的药物治疗效果各不相同，且无法治愈，这凸显了需要改进治疗方法。此外，溃疡性结肠炎患者发生结直肠癌的风险增加。一些天然来源的药物，称为营养保健品，被发现具有抗炎和抗氧化特性。特别值得关注的是鸸鹋油、葡萄籽提取物和日本汉方药。以前，鸸鹋油已在包括结肠炎和结肠炎相关结直肠癌在内的胃肠道疾病模型中保护和修复肠道损伤。此外，葡萄籽提取物在体外具有抗癌特性。此外，汉方药由草药成分组成，在日本被广泛用于治疗各种疾病，并已证明在体外靶向癌细胞方面有效。营养保健品联合使用在结肠炎相关结直肠癌的治疗中尚未得到广泛研究。研究鸸鹋油与其他营养保健品（包括葡萄籽提取物和汉方药）联合使用的疗效是合理的，因为它们可能为传统的结肠炎和结直肠癌治疗提供一种新方法。
