Department of Gastroenterology, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
J Gastroenterol Hepatol. 2012 May;27(5):857-61. doi: 10.1111/j.1440-1746.2012.07098.x.
Gastrointestinal diseases characterized by inflammation, including the inflammatory bowel diseases, chemotherapy-induced mucositis and non-steroidal anti-inflammatory drug-induced enteropathy, currently have variably effective treatment options, highlighting the need for novel therapeutic approaches. Recently, naturally-sourced agents including prebiotics, probiotics, plant-extracts and marine-derived oils known to possess anti-inflammatory and anti-oxidant properties have been investigated in vitro and in vivo. However, animal-derived oils are yet to be extensively tested. Emu Oil is extracted from the subcutaneous and retroperitoneal fat of the Emu, a flightless bird native to Australia, and predominantly comprises fatty acids. Despite the limited rigorous scientific studies conducted to date, with largely anecdotal claims, Emu Oil, when administered topically and orally, has been shown to possess significant anti-inflammatory properties in vivo. These include a CD-1 mouse model of croton oil-induced auricular inflammation, experimentally-induced polyarthritis and dextran sulfate sodium-induced colitis. Recently, Emu Oil has been demonstrated to endow partial protection against chemotherapy-induced mucositis, with early indications of improved intestinal repair. Emu Oil could therefore form the basis of an adjunct to conventional treatment approaches for inflammatory disorders affecting the gastrointestinal system.
以炎症为特征的胃肠道疾病，包括炎症性肠病、化疗诱导的粘膜炎和非甾体抗炎药诱导的肠病，目前有不同疗效的治疗选择，这突出表明需要新的治疗方法。最近，已经在体外和体内研究了包括益生菌、植物提取物和海洋衍生油在内的天然来源的药物，这些药物具有抗炎和抗氧化特性。然而，动物源性油尚未得到广泛测试。鸸鹋油是从鸸鹋（一种原产于澳大利亚的不会飞的鸟类）的皮下和腹膜后脂肪中提取的，主要由脂肪酸组成。尽管迄今为止进行的严格科学研究有限，且主要是轶事证据，但局部和口服给予鸸鹋油已被证明在体内具有显著的抗炎特性。这些特性包括 CD-1 小鼠角叉菜胶诱导的耳炎模型、实验性多关节炎和葡聚糖硫酸钠诱导的结肠炎。最近，鸸鹋油被证明对化疗诱导的粘膜炎有一定的保护作用，并显示出改善肠道修复的早期迹象。因此，鸸鹋油可以作为治疗影响胃肠道系统的炎症性疾病的常规治疗方法的辅助手段。
