University of Muenster, Muenster, Germany; Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Muenster, Germany.
University of Muenster, Muenster, Germany; Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Muenster, Germany; Max Planck Institute for Molecular Biomedicine, Muenster, Germany.
Dev Biol. 2020 Jan 15;457(2):181-190. doi: 10.1016/j.ydbio.2019.03.005. Epub 2019 Mar 9.
To ensure tissue homeostasis the brain needs to be protected from blood-derived fluctuations or pathogens that could affect its function. Therefore, the brain capillaries develop tissue-specific properties to form a selective blood-brain barrier (BBB), allowing the passage of essential molecules to the brain and blocking the penetration of potentially harmful compounds or cells. Previous studies reported the presence of this barrier in zebrafish. The intrinsic features of the zebrafish embryos and larvae in combination with optical techniques, make them suitable for the study of barrier establishment and maturation. In this review, we discuss the most recent contributions to the development and formation of a functional zebrafish BBB. Moreover, we compare the molecular and cellular characteristic of the zebrafish and the mammalian BBB.
为了确保组织的内稳态，大脑需要免受血液来源的波动或可能影响其功能的病原体的影响。因此，脑毛细血管发展出组织特异性的特性，形成一个选择性的血脑屏障（BBB），允许必需的分子进入大脑，并阻止潜在有害的化合物或细胞的渗透。先前的研究报告了这种屏障在斑马鱼中的存在。斑马鱼胚胎和幼虫的固有特性结合光学技术，使它们适合于研究屏障的建立和成熟。在这篇综述中，我们讨论了在斑马鱼功能性 BBB 的发育和形成方面的最新进展。此外，我们还比较了斑马鱼和哺乳动物 BBB 的分子和细胞特征。
