Program in Genomics of Differentiation, Laboratory of Molecular Genetics, Section on Vertebrate Organogenesis, NICHD, NIH, Bethesda, Maryland, USA.
Cold Spring Harb Perspect Med. 2012 May;2(5):a006684. doi: 10.1101/cshperspect.a006684.
The zebrafish has emerged as an excellent vertebrate model system for studying blood and lymphatic vascular development. The small size, external and rapid development, and optical transparency of zebrafish embryos are some of the advantages the zebrafish model system offers. Multiple well-established techniques have been developed for imaging and functionally manipulating vascular tissues in zebrafish embryos, expanding on and amplifying these basic advantages and accelerating use of this model system for studying vascular development. In the past decade, studies performed using zebrafish as a model system have provided many novel insights into vascular development. In this article we discuss the amenability of this model system for studying blood vessel development and review contributions made by this system to our understanding of vascular development.
斑马鱼已成为研究血液和淋巴血管发育的优秀脊椎动物模型系统。斑马鱼模型系统的优势包括其体型小、体外发育且发育迅速、胚胎光学透明等。目前已经开发出多种成熟的技术，可用于对斑马鱼胚胎中的血管组织进行成像和功能操作，进一步扩展和放大了这些基本优势，并加速了该模型系统在血管发育研究中的应用。在过去十年中，使用斑马鱼作为模型系统进行的研究为血管发育提供了许多新的见解。本文我们讨论了该模型系统在研究血管生成方面的适用性，并回顾了该系统对我们理解血管生成的贡献。
