Nakao M, Kondo M, Imada A
J Antimicrob Chemother. 1986 Apr;17(4):433-9. doi: 10.1093/jac/17.4.433.
The in-vitro bactericidal and bacteriolytic activities and the effect on bacterial morphology of carumonam, a new N-sulfonated monocyclic beta-lactam antibiotic, against aerobic Gram-negative bacilli were compared with those of aztreonam. Both antibiotics, at their minimal inhibitory concentration (MIC) levels, were strongly bactericidal against species of Enterobacteriaceae, but weakly bactericidal against Pseudomonas aeruginosa. Their bactericidal activity was not increased by increasing the antibiotic concentration above the MICs. In contrast to this potent bactericidal activity, the bacteriolytic activity of carumonam and aztreonam was low and limited to enteric bacterial species like Escherichia coli. Filamentation was the major morphological change of Gram-negative bacilli after exposure to carumonam and aztreonam. E. coli and Serratia marcescens, but not P. aeruginosa, were converted to ghosts after prolonged incubation with carumonam.
将新型N-磺化单环β-内酰胺抗生素卡芦莫南对需氧革兰氏阴性杆菌的体外杀菌和溶菌活性以及对细菌形态的影响与氨曲南进行了比较。两种抗生素在其最低抑菌浓度（MIC）水平时，对肠杆菌科细菌均有强烈的杀菌作用，但对铜绿假单胞菌的杀菌作用较弱。将抗生素浓度增加至高于MIC水平时，其杀菌活性并未增强。与这种强大的杀菌活性相反，卡芦莫南和氨曲南的溶菌活性较低，且仅限于大肠杆菌等肠道细菌种类。丝状化是革兰氏阴性杆菌暴露于卡芦莫南和氨曲南后的主要形态变化。长时间与卡芦莫南孵育后，大肠杆菌和粘质沙雷氏菌会变成菌影，但铜绿假单胞菌不会。
