Division of Gastroenterology and Hepatology, Graduate school of medical and dental sciences, Niigata University, Chuo-ku, Niigata 951-8510, Japan.
Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, the University of Birmingham, Birmingham B15 2TT, United Kingdom.
World J Gastroenterol. 2019 Mar 7;25(9):1037-1049. doi: 10.3748/wjg.v25.i9.1037.
The liver has a high regenerative capacity after acute liver injury, but this is often impaired during chronic liver injury. The existence of a dedicated liver stem cell population that acts as a source of regeneration during chronic liver injury has been controversial. Recent advances in transgenic models and cellular reprogramming have provided new insights into the plasticity of the liver epithelium and directions for the development of future therapies. This article will highlight recent findings about the cellular source of regeneration during liver injury and the advances in promoting liver regeneration.
肝脏在急性肝损伤后具有很强的再生能力，但在慢性肝损伤时这种能力往往受损。在慢性肝损伤时，是否存在一种专门的肝干细胞群体作为再生的来源一直存在争议。近年来，转基因模型和细胞重编程方面的进展为肝上皮细胞的可塑性提供了新的见解，并为未来治疗方法的发展指明了方向。本文将重点介绍肝损伤时再生的细胞来源的最新发现，以及促进肝再生的最新进展。
