关于BVES/POPDC1在人类疾病中作用的十年研究综述
Ten years of research on the role of BVES/ POPDC1 in human disease: a review.
作者信息
Han Ping, Lei Yu, Li Dongxiao, Liu Jingmei, Yan Wei, Tian Dean
机构信息
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China,
出版信息
Onco Targets Ther. 2019 Feb 18;12:1279-1291. doi: 10.2147/OTT.S192364. eCollection 2019.
Since the blood vessel epicardial substance or Popeye domain-containing protein 1 (BVES/POPDC1) was first identified in the developing heart by two independent laboratories in 1999, an increasing number of studies have investigated the structure, function, and related diseases of BVES/POPDC1. During the first 10 years following the discovery of BVES/POPDC1, studies focused mainly on its structure, expression patterns, and functions. Based on these studies, further investigations conducted over the previous decade examined the role of BVES/POPDC1 in human diseases, such as colitis, heart diseases, and human cancers. This review provides an overview of the structure and expression of BVES/POPDC1, mainly focusing on its potential role and mechanism through which it is involved in human cancers.
自1999年两个独立实验室首次在发育中的心脏中鉴定出血管心外膜物质或含大力水手结构域蛋白1（BVES/POPDC1）以来，越来越多的研究对BVES/POPDC1的结构、功能及相关疾病进行了探究。在BVES/POPDC1被发现后的最初10年里，研究主要集中在其结构、表达模式和功能上。基于这些研究，在过去十年中进行的进一步调查研究了BVES/POPDC1在人类疾病中的作用，如结肠炎、心脏病和人类癌症。本综述概述了BVES/POPDC1的结构和表达，主要关注其在人类癌症中的潜在作用及作用机制。
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