Hamoudi Zina, Khuong Thang Manh, Cole Tiffany, Neely G Gregory
University of Sydney, Charles Perkins Centre and School of Life and Environmental Sciences, Camperdown, New South Wales, Australia.
University of Sydney, Dr. John and Anne Chong Lab for Functional Genomics, Camperdown, New South Wales, Australia.
F1000Res. 2018 Jan 23;7:99. doi: 10.12688/f1000research.13581.2. eCollection 2018.
: Paclitaxel-induced peripheral neuropathy is a common and limiting side effect of an approved and effective chemotherapeutic agent. The cause of this nociception is still unknown. : To uncover the mechanism involved in paclitaxel-induced pain, we developed a thermal nociceptive model to show the effects of paclitaxel exposure on third instar larvae. : We found that paclitaxel increases heat nociception in a dose-dependent manner, and at the highest doses also obstructs dendritic repulsion cues. : Our simple system can be applied to identify regulators of chemotherapy-induced pain and may help to eliminate pain-related side-effects of chemotherapy.
紫杉醇引起的周围神经病变是一种已获批且有效的化疗药物常见的限制性副作用。这种伤害感受的原因仍然未知。为了揭示紫杉醇诱导疼痛所涉及的机制，我们建立了一个热伤害感受模型来展示紫杉醇暴露对三龄幼虫的影响。我们发现紫杉醇以剂量依赖的方式增加热伤害感受，并且在最高剂量时还会阻碍树突排斥信号。我们这个简单的系统可用于识别化疗诱导疼痛的调节因子，并可能有助于消除化疗相关的疼痛副作用。
