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J Biol Chem. 2020 Dec 18;295(51):17497-17513. doi: 10.1074/jbc.RA120.013428.
2
Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington's disease.过量的 Rab4 挽救了亨廷顿病中 HTT-Rab4 轴突运输缺陷引起的突触和行为功能障碍。
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Injured adult neurons regress to an embryonic transcriptional growth state.成年受损神经元退回到胚胎转录生长状态。
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Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling.氯喹和巴弗洛霉素 A 模拟溶酶体储存障碍并损害 mTORC1 信号。
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SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals.SIPA1L2 控制含有 TrkB 的内体小泡在突触前末端的运输和局部信号转导。
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Excess active P13K rescues huntingtin-mediated neuronal cell death but has no effect on axonal transport defects.过度活跃的 P13K 可挽救亨廷顿氏病介导的神经元细胞死亡，但对轴突运输缺陷没有影响。
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HTT（亨廷顿蛋白）和 RAB7 共同逆行迁移到轴突损伤过程中含有信号 LAMP1 的晚期内体上。

HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury.

机构信息

Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, USA.

出版信息

Autophagy. 2023 Apr;19(4):1199-1220. doi: 10.1080/15548627.2022.2119351. Epub 2022 Sep 9.

DOI:10.1080/15548627.2022.2119351
PMID:36048753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10012955/
Abstract

Atg5: Autophagy-related 5; Atg8a: Autophagy-related 8a; AL: autolysosome; AP: autophagosome; BAF1: bafilomycin A; BDNF: brain derived neurotrophic factor; BMP: bone morphogenetic protein; Cyt-c-p: Cytochrome c proximal; CQ: chloroquine; DCTN1: dynactin 1; Dhc: dynein heavy chain; EE: early endosome; DYNC1I1: dynein cytoplasmic 1 intermediate chain 1; HD: Huntington disease; HIP1/Hip1: huntingtin interacting protein 1; HTT/htt: huntingtin; iNeuron: iPSC-derived human neurons; IP: immunoprecipitation; Khc: kinesin heavy chain; KIF5C: kinesin family member 5C; LAMP1/Lamp1: lysosomal associated membrane protein 1; LE: late endosome; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K12/DLK: mitogen-activated protein kinase kinase kinase 12; MAPK8/JNK/bsk: mitogen-activated protein kinase 8/basket; MAPK8IP3/JIP3: mitogen-activated protein kinase 8 interacting protein 3; NGF: nerve growth factor; NMJ: neuromuscular junction; NTRK1/TRKA: neurotrophic receptor tyrosine kinase 1; NRTK2/TRKB: neurotrophic receptor tyrosine kinase 2; nuf: nuclear fallout; PG: phagophore; PtdIns3P: phosphatidylinositol-3-phosphate; puc: puckered; ref(2)P: refractory to sigma P; Rilpl: Rab interacting lysosomal protein like; Rip11: Rab11 interacting protein; RTN1: reticulon 1; syd: sunday driver; SYP: synaptophysin; SYT1/Syt1: synaptotagmin 1; STX17/Syx17: syntaxin 17; tkv: thickveins; VF: vesicle fraction; wit: wishful thinking; wnd: wallenda.

摘要

Atg5：自噬相关 5；Atg8a：自噬相关 8a；AL：自溶体；AP：自噬体；BAF1：巴弗洛霉素 A；BDNF：脑源性神经营养因子；BMP：骨形态发生蛋白；Cyt-c-p：细胞色素 c 近端；CQ：氯喹；DCTN1：动力蛋白 1 复合物亚基 1；Dhc：动力蛋白重链；EE：早期内体；DYNC1I1：动力蛋白细胞质 1 中间链 1；HD：亨廷顿病；HIP1/Hip1：亨廷顿蛋白相互作用蛋白 1；HTT/htt：亨廷顿蛋白；iNeuron：iPSC 衍生的人类神经元；IP：免疫沉淀；Khc：驱动蛋白重链；KIF5C：驱动蛋白家族成员 5C；LAMP1/Lamp1：溶酶体相关膜蛋白 1；LE：晚期内体；MAP1LC3/LC3：微管相关蛋白 1 轻链 3；MAP3K12/DLK：丝裂原活化蛋白激酶激酶激酶 12；MAPK8/JNK/bsk：丝裂原活化蛋白激酶 8/篮子；MAPK8IP3/JIP3：丝裂原活化蛋白激酶 8 相互作用蛋白 3；NGF：神经生长因子；NMJ：神经肌肉接头；NTRK1/TRKA：神经营养受体酪氨酸激酶 1；NRTK2/TRKB：神经营养受体酪氨酸激酶 2；nuf：核沉降物；PG：吞噬体；PtdIns3P：磷脂酰肌醇-3-磷酸；puc：皱缩；ref(2)P：对 sigma P 有抗性；Rilpl：Rab 相互作用溶酶体蛋白样；Rip11：Rab11 相互作用蛋白；RTN1：网蛋白 1；syd：周日司机；SYP：突触小体蛋白；SYT1/Syt1：突触结合蛋白 1；STX17/Syx17：突触小泡蛋白 17；tkv：厚翅；VF：囊泡级分；wit：一厢情愿；wnd：瓦伦达。