Cainelli Francesca, Hortelano Gonzalo, Negmetzhanov Baurzhan, Ibrayeva Aigerim, Kaliaskarova Kulpash, Bulanin Denis, Vento Sandro
Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Department of Biology, School of Science and Technology, Nazarbayev University, Astana, Kazakhstan.
Cent Asian J Glob Health. 2018 Feb 22;7(1):324. doi: 10.5195/cajgh.2018.324. eCollection 2018.
Hepatitis E virus exposure is associated with sporadic cases of acute hepatitis and outbreaks in many countries worldwide. It is particularly dangerous for pregnant women, in whom the mortality rate is high. There are no previously published data reporting circulation of this virus in Kazakhstan.
We tested blood samples for IgG anti-hepatitis E virus antibodies in 199 Kazakh participants; of these 119 were workers at the EXPO 2017 building site in Astana, 35 were volunteers who got tested at the Astana City Hall on the World Hepatitis Day 2017, and 45 were volunteers who presented for screening at the Hepatogastroenterology Outpatient Clinic of the Republican Diagnostic Center, University Medical Center.
11 (5.5%) individuals were positive for IgG anti-HEV antibodies, with a higher seroprevalence in males (7; 6.8%) vs females (4; 4.5%). The highest number of positive samples was in the 32-46 years age group.
This pilot study suggests that Hepatitis E virus has been circulating in Kazakhstan. Studies are needed to determine whether it continues to be present, which viral genotypes are involved and what are the best methodologies for preventing its spread.
戊型肝炎病毒感染与全球许多国家的散发性急性肝炎病例和疫情爆发有关。对孕妇来说，它尤其危险，孕妇的死亡率很高。此前尚无关于该病毒在哈萨克斯坦传播情况的公开数据。
我们检测了199名哈萨克斯坦参与者血液样本中的抗戊型肝炎病毒IgG抗体；其中119人是2017年阿斯塔纳世博会建筑工地的工人，35人是在2017年世界肝炎日于阿斯塔纳市政厅接受检测的志愿者，45人是在大学医学中心共和诊断中心胃肠肝病门诊接受筛查的志愿者。
11人（5.5%）抗戊型肝炎病毒IgG抗体呈阳性，男性的血清阳性率（7人；6.8%）高于女性（4人；4.5%）。阳性样本数量最多的是32 - 46岁年龄组。
这项初步研究表明戊型肝炎病毒已在哈萨克斯坦传播。需要开展研究以确定该病毒是否持续存在、涉及哪些病毒基因型以及预防其传播的最佳方法是什么。
