Department of Nephrology, Dialysis and Organ Transplantation, Centre Hospitalier Universitaire Rangueil, Toulouse, France.
Emerg Infect Dis. 2011 Feb;17(2):173-9. doi: 10.3201/eid1702.100856.
Information about the spectrum of disease caused by hepatitis E virus (HEV) genotype 3 is emerging. During 2004-2009, at 2 hospitals in the United Kingdom and France, among 126 patients with locally acquired acute and chronic HEV genotype 3 infection, neurologic complications developed in 7 (5.5%): inflammatory polyradiculopathy (n = 3), Guillain-Barre syndrome (n = 1), bilateral brachial neuritis (n = 1), encephalitis (n = 1), and ataxia/proximal myopathy (n = 1). Three cases occurred in nonimmunocompromised patients with acute HEV infection, and 4 were in immunocompromised patients with chronic HEV infection. HEV RNA was detected in cerebrospinal fluid of all 4 patients with chronic HEV infection but not in that of 2 patients with acute HEV infection. Neurologic outcomes were complete resolution (n = 3), improvement with residual neurologic deficit (n = 3), and no improvement (n = 1). Neurologic disorders are an emerging extrahepatic manifestation of HEV infection.
有关戊型肝炎病毒（HEV）基因型 3 引起的疾病谱的信息正在出现。在 2004 年至 2009 年期间，在英国和法国的 2 家医院中，在 126 例本地获得性急性和慢性 HEV 基因型 3 感染患者中，有 7 例（5.5%）出现神经系统并发症：炎症性多神经根病（n = 3）、格林-巴利综合征（n = 1）、双侧臂丛神经炎（n = 1）、脑炎（n = 1）和共济失调/近端肌病（n = 1）。3 例发生在急性 HEV 感染的非免疫功能低下患者中，4 例发生在慢性 HEV 感染的免疫功能低下患者中。在所有 4 例慢性 HEV 感染患者的脑脊液中均检测到 HEV RNA，但在 2 例急性 HEV 感染患者的脑脊液中未检测到。神经系统结局为完全缓解（n = 3）、改善但仍有神经功能缺损（n = 3）和无改善（n = 1）。神经系统疾病是 HEV 感染的一种新的肝外表现。
