Chandran Suhas, Raman Rajesh, Kishor M, Nandeesh H P
Department of Psychiatry, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysore-Bangalore Road, Bannimantap, Mysuru, 570 015, India.
Department of Gastroenterology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysore-Bangalore Road, Bannimantap, Mysuru, 570 015, India.
Indian J Gastroenterol. 2019 Feb;38(1):29-38. doi: 10.1007/s12664-019-00940-z. Epub 2019 Mar 13.
The role of psychological comorbidities in patients with gastroesophageal reflux disease (GERD), a common condition, still remains incompletely understood. Depression may intensify the symptoms and lower quality of life in these patients. In this study, we looked at the effectiveness of mindfulness-based stress reduction (MBSR) in relieving the symptoms of depression and the health-related quality of life of these patients.
A longitudinal, interventional open-label study was carried out on 60 patients with GERD and 60 controls. Zung Self-Rating Depression Scale (ZSDS) was used for assessing depression before and after the intervention. The GERD-Health-Related Quality of Life (GERD-HRQL) questionnaire was used to assess the health-related quality of life and the Freiburg Mindfulness Inventory (FMI) to quantify the amount of mindfulness over the study period. The correlation between the above variables was analyzed.
Compared with the group not receiving MBSR, the group receiving MBSR showed a greater decrease in the levels of depression indicated by changes in the ZSDS (p < 0.001). According to the GERD-HRQL questionnaire, mental health and social functioning significantly correlated with symptoms of depression and reduction in the levels of distress and in the improvement in health-related quality of life were greater in the group receiving MBSR (p < 0.001).
Depressive symptoms adversely influence GERD, reducing the overall quality of life. MBSR can be an effective modality in the alleviation of these symptoms and in reduction in the levels of distress in GERD patients.
心理共病在胃食管反流病（GERD，一种常见病症）患者中的作用仍未完全明确。抑郁症可能会加重这些患者的症状并降低其生活质量。在本研究中，我们探讨了基于正念减压疗法（MBSR）在缓解这些患者的抑郁症状及改善其健康相关生活质量方面的有效性。
对60例GERD患者和60例对照者进行了一项纵向、干预性开放标签研究。采用zung自评抑郁量表（ZSDS）评估干预前后的抑郁情况。使用GERD健康相关生活质量（GERD-HRQL）问卷评估健康相关生活质量，并用弗莱堡正念量表（FMI）量化研究期间的正念程度。分析上述变量之间的相关性。
与未接受MBSR的组相比，接受MBSR的组中，ZSDS变化所显示的抑郁水平下降幅度更大（p < 0.001）。根据GERD-HRQL问卷，心理健康和社会功能与抑郁症状显著相关，接受MBSR的组中痛苦程度降低及健康相关生活质量改善更为明显（p < 0.001）。
抑郁症状对GERD有不利影响，降低了总体生活质量。MBSR可能是缓解这些症状及降低GERD患者痛苦程度的有效方式。
