Department of Surgery-Transplant, University of Nebraska Medical Center, Omaha, Nebraska.
Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska.
J Diabetes. 2019 Aug;11(8):632-644. doi: 10.1111/1753-0407.12915. Epub 2019 Apr 22.
Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from destruction of the insulin-producing pancreatic β-cells. The disease mainly affects juveniles. Changes in the composition of the gut microbiota (dysbiosis) and changes in the properties of the gut barrier have been documented in T1D subjects. Because these factors affect immune system functions, they are likely to play a role in disease pathogenesis. However, their exact role is currently not fully understood and is under intensive investigation. In this article we discuss recent advancements depicting the role of intestinal dysbiosis on immunity and autoimmunity in T1D. We also discuss therapies aimed at maintaining a healthy gut barrier as prevention strategies for T1D.
1 型糖尿病（T1D）是一种慢性自身免疫性疾病，由产生胰岛素的胰腺β细胞破坏引起。这种疾病主要影响青少年。在 T1D 患者中已经记录到肠道微生物群落组成的变化（失调）和肠道屏障特性的变化。由于这些因素影响免疫系统功能，它们可能在疾病发病机制中起作用。然而，它们的确切作用目前尚不完全清楚，并正在进行深入研究。本文讨论了描述肠道失调对 T1D 中免疫和自身免疫作用的最新进展。我们还讨论了旨在维持健康肠道屏障的治疗方法，作为 T1D 的预防策略。
