Kruger T E, Blalock J E
J Immunol. 1986 Jul 1;137(1):197-200.
We reported previously that thyrotropin (TSH) enhanced the in vitro antibody response to a T cell-dependent antigen, sheep red blood cells (SRBC), as determined by direct plaque-forming cell (PFC) assay. The present studies were designed to determine the possible immunoregulatory function of TSH on lymphocytes immunized with the T-independent antigen Brucella abortus-TNP (BA-TNP) and the cellular components involved in such function. We report here that TSH enhanced the in vitro antibody response to BA-TNP as determined by direct PFC assays. Cell depletion studies showed that the TSH effect, although independent of macrophages, required the presence of T cells. Thus, pituitary--and possibly leukocyte--TSH appears to function as a lymphokine which may act via T cells to augment antibody production.
我们先前报道，通过直接空斑形成细胞（PFC）测定发现，促甲状腺激素（TSH）可增强体外对T细胞依赖性抗原绵羊红细胞（SRBC）的抗体反应。本研究旨在确定TSH对用非T细胞依赖性抗原流产布鲁氏菌 - 三硝基苯（BA-TNP）免疫的淋巴细胞可能具有的免疫调节功能以及参与该功能的细胞成分。我们在此报告，通过直接PFC测定发现TSH增强了体外对BA-TNP的抗体反应。细胞耗竭研究表明，TSH的作用虽然不依赖于巨噬细胞，但需要T细胞的存在。因此，垂体以及可能的白细胞TSH似乎起到淋巴因子的作用，它可能通过T细胞来增强抗体产生。
