硫酸脱氢表雄酮水平低与老年人心血管自主神经功能障碍的发生风险相关。

Low levels of dehydroepiandrosterone sulfate are associated with the risk of developing cardiac autonomic dysfunction in elderly subjects.

作者信息

Lemos Marina de Paiva, Miranda Munique Tostes, Marocolo Moacir, Resende Elisabete Aparecida Mantovani Rodrigues de, Chriguer Rosângela Soares, Sordi Carla Cristina de, Barbosa Neto Octávio

机构信息

Departamento de Ciências do Esporte, Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brasil.

Departamento de Fisiologia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.

出版信息

Arch Endocrinol Metab. 2019 Feb;63(1):62-69. doi: 10.20945/2359-3997000000104.

DOI:10.20945/2359-3997000000104

PMID:30864633

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10118840/

Abstract

OBJECTIVE

To assess the relationships between serum dehydroepiandrosterone sulfate (DHEA-S) levels and heart rate variability (HRV) among different age groups.

SUBJECTS AND METHODS

Forty-five healthy men were divided into 3 groups: young age (YA; 20-39 yrs; n = 15), middle age (MA; 40-59 yrs; n = 15) and old age (OA; ≥ 60 yrs; n = 15). Hemodynamic parameters, linear analyses of HRV and concentrations of cortisol and DHEA-S were measured at rest.

RESULTS

The OA group presented a higher resting heart rate (84.3 ± 4.6 bpm) than the YA group (72.0 ± 4.4 bpm; p < 0.05). The YA group showed an attenuated variance of HRV (2235.1 ± 417.9 ms2) compared to the MA (1014.3 ± 265.2 ms2; p < 0.05) and OA (896.3 ± 274.1 ms2; p < 0.05) groups, respectively. The parasympathetic modulation of HRV was lower in both the MA (244.2 ± 58.0 ms2) and OA (172.8 ± 37.9 ms2) groups in comparison with the YA group (996.0 ± 255.4 ms2; p < 0.05), while serum DHEA-S levels were significantly lower in both the MA (91.2 ± 19.6 mg/dL) and OA (54.2 ± 17.7 mg/dL) groups compared to the YA group (240.0 ± 50.8 mg/dL; p < 0.05). A positive correlation between lower serum concentrations of DHEA-S and attenuated variance of HRV (r = 0.47, p = 0.031), as well as lower serum concentrations of DHEA-S and decreased parasympathetic modulation of HRV (r = 0.54, p = 0.010), were found.

CONCLUSION

The present study demonstrated that the decline of plasma DHEA-S is associated with reduced cardiac autonomic modulation during the aging process.

摘要

目的

评估不同年龄组血清硫酸脱氢表雄酮（DHEA-S）水平与心率变异性（HRV）之间的关系。

对象与方法

45名健康男性被分为3组：青年组（YA；20 - 39岁；n = 15）、中年组（MA；40 - 59岁；n = 15）和老年组（OA；≥60岁；n = 15）。静息状态下测量血流动力学参数、HRV的线性分析以及皮质醇和DHEA-S的浓度。

结果

老年组静息心率（84.3±4.6次/分钟）高于青年组（72.0±4.4次/分钟；p < 0.05）。与中年组（1014.3±265.2 ms²；p < 0.05）和老年组（896.3±274.1 ms²；p < 0.05）相比，青年组HRV的方差减小（2235.1±417.9 ms²）。与青年组（996.0±255.4 ms²；p < 0.05）相比，中年组（244.2±58.0 ms²）和老年组（172.8±37.9 ms²）HRV的副交感神经调节均较低，而中年组（91.2±19.6 mg/dL）和老年组（54.2±17.7 mg/dL）的血清DHEA-S水平均显著低于青年组（240.0±50.8 mg/dL；p < 0.05）。发现血清DHEA-S浓度降低与HRV方差减小之间存在正相关（r = 0.47，p = 0.031），以及血清DHEA-S浓度降低与HRV的副交感神经调节降低之间存在正相关（r = 0.54，p = 0.010）。