Villoing Daphnée, Lee Ae-Kyoung, Choi Hyung-do, Lee Choonsik
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.
Radio & Satellite Research Division, Electronics and Telecommunications Research Institute, Daejeo 34129, South Korea.
Radiat Prot Dosimetry. 2019 Dec 23;185(2):168-175. doi: 10.1093/rpd/ncy287.
Over the past decades, the application of single-photon emission computed tomography and positron emission tomography in neuroimaging has markedly increased. In the current study, we used a series of Korean computational head phantoms with detailed cranial structures for 6-, 9-, 12-, 15-y-old children and adult and a Monte Carlo transport code, MCNPX, to calculate age-dependent specific absorbed fraction (SAF) for mono-energetic electrons ranging from 0.01 to 4 MeV and S values for seven radionuclides widely used in nuclear medicine neuroimaging for the combination of ten source and target regions. Compared to the adult phantom, the 6-y phantom showed up to 1.7-fold greater SAF (cerebellum < cerebellum) and up to 1.4-fold greater S values (vitreous body < lens) for 123I. The electron SAF data, combined with our previous photon SAF data, will facilitate absorbed dose calculations for various cranial structures in patients undergoing neuroimaging procedures.
在过去几十年中,单光子发射计算机断层扫描和正电子发射断层扫描在神经成像中的应用显著增加。在本研究中,我们使用了一系列具有详细颅骨结构的韩国计算头部模型,这些模型适用于6岁、9岁、12岁、15岁儿童及成人,并用蒙特卡罗传输代码MCNPX计算了能量范围从0.01到4 MeV的单能电子的年龄依赖性比吸收分数(SAF)以及核医学神经成像中广泛使用的七种放射性核素在十个源区和靶区组合下的S值。与成人模型相比,6岁模型对于123I的SAF(小脑<小脑)高达1.7倍,S值(玻璃体<晶状体)高达1.4倍。电子SAF数据与我们之前的光子SAF数据相结合,将有助于对接受神经成像检查的患者各种颅骨结构的吸收剂量进行计算。