通过非芳构化激活机制进行 3,5-二甲基-4-(2'-苯乙炔基苯基)苯基(EPP)糖苷化。
Glycosylation with 3,5-Dimethyl-4-(2'-phenylethynylphenyl)phenyl (EPP) Glycosides via a Dearomative Activation Mechanism.
机构信息
School of Physical Science and Technology , ShanghaiTech University , 100 Haike Road , Shanghai 201210 , China.
State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis , Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Road , Shanghai 200032 , China.
出版信息
J Am Chem Soc. 2019 Mar 27;141(12):4806-4810. doi: 10.1021/jacs.9b00210. Epub 2019 Mar 15.
A highly effective and versatile glycosylation method is developed, which uses 3,5-dimethyl-4-(2'-phenylethynylphenyl)phenyl (EPP) glycosides as donors and NIS/TMSOTf as promoter and proceeds via an unprecedented dearomative activation mechanism.
发展了一种高效、通用的糖苷化方法，该方法以 3,5-二甲基-4-(2'-苯乙炔基苯基)苯基(EPP)糖苷作为供体，以 NIS/TMSOTf 作为促进剂，通过前所未有的去芳构化激活机制进行反应。
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