Department of Otolaryngology - Head and Neck Surgery, Cancer Center Amsterdam (CCA), Amsterdam Public Health Research Institute, Amsterdam UMC, location VUmc, Amsterdam.
Department of Clinical, Neuro and Development Psychology, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, Amsterdam.
Psychooncology. 2019 Jun;28(6):1159-1183. doi: 10.1002/pon.5058. Epub 2019 May 9.
To systematically review the literature on factors associated with a clinical diagnosis of depression or symptoms of depression (depression) among head and neck cancer (HNC) patients.
The search was conducted in PubMed, PsycINFO, and CINAHL. Studies were included if they investigated factors associated with depression among HNC patients, they were of prospective or longitudinal nature, and English full text was available. The search, data extraction, and quality assessment were performed by two authors. Based on the data extraction and quality assessment, the level of evidence was determined.
In total, 35 studies were included: 21 on factors associated with depression at a single (later) time point, 10 on the course of depression, and four on both. In total, 77 sociodemographic, lifestyle, clinical, patient-reported outcome measures, and inflammatory factors were extracted. Regarding depression at a single time point, there was strong evidence that depression at an earlier time point was significantly associated. For all other factors, evidence was inconclusive, although evidence suggests that age, marital status, education, ethnicity, hospital/region, sleep, smoking, alcohol, surgery, treatment, tumor location, and recurrence are not important associated factors. Regarding the course of depression, we found inconclusive evidence for all factors, although evidence suggests that gender, age, chemotherapy, pain, disease stage, treatment, and tumor location are not important associated factors.
Depression at an earlier time point is significantly associated with depression later on. Several sociodemographic and clinical factors seem not to be important factors associated with depression. For other factors, further research is warranted.
系统回顾与头颈部癌症（HNC）患者临床诊断或抑郁症状（抑郁）相关的文献。
在 PubMed、PsycINFO 和 CINAHL 中进行搜索。如果研究调查了与 HNC 患者抑郁相关的因素，且为前瞻性或纵向研究，并且提供英文全文，则将其纳入研究。两名作者进行了搜索、数据提取和质量评估。根据数据提取和质量评估，确定了证据水平。
共纳入 35 项研究：21 项研究与单一（后期）时间点的抑郁相关因素有关，10 项研究与抑郁的病程有关，4 项研究同时与两者有关。共提取了 77 个社会人口统计学、生活方式、临床、患者报告的结果测量和炎症因素。关于单一时间点的抑郁，有强有力的证据表明早期的抑郁与抑郁显著相关。对于所有其他因素，证据不确定，尽管有证据表明年龄、婚姻状况、教育程度、种族、医院/地区、睡眠、吸烟、饮酒、手术、治疗、肿瘤部位和复发不是重要的相关因素。关于抑郁的病程，我们发现所有因素的证据都不确定，尽管有证据表明性别、年龄、化疗、疼痛、疾病分期、治疗和肿瘤部位不是重要的相关因素。
早期的抑郁与后期的抑郁显著相关。一些社会人口统计学和临床因素似乎不是与抑郁相关的重要因素。对于其他因素，需要进一步研究。
