尼二萜 A 和 B：来自于构巢曲霉的两个六元环稠合的高度拥挤的[5/5/5/5/3/5]桥环体系的倍半萜。
Niduterpenoids A and B: Two Sesterterpenoids with a Highly Congested Hexacyclic 5/5/5/5/3/5 Ring System from the Fungus Aspergillus nidulans.
机构信息
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430030 , People's Republic of China.
College of Pharmacy , Hubei University of Medicine , Shiyan 442000 , People's Republic of China.
出版信息
Org Lett. 2019 Apr 5;21(7):2290-2293. doi: 10.1021/acs.orglett.9b00581. Epub 2019 Mar 13.
Niduterpenoids A (1) and B (2), two sesterterpenoids with a highly congested hexacyclic 5/5/5/5/3/5 carbon skeleton but no unsaturated functional group, were isolated from Aspergillus nidulans. Their structures were determined by a combination of spectroscopic data and single-crystal X-ray diffraction analyses. Compounds 1 and 2 present the first examples of sesterterpenoids with a hexacyclic carbon ring system. Compound 1 showed no cytotoxicity but abolished 17-estradiol-induced cell proliferation (IC = 11.42 ± 0.85 μM).
尼二萜 A（1）和 B（2）是从构巢曲霉中分离得到的两个具有高度拥挤的六环 5/5/5/5/3/5 碳骨架但没有不饱和官能团的甾体二萜。它们的结构通过光谱数据和单晶 X 射线衍射分析相结合确定。化合物 1 和 2 是具有六环碳环系统的甾体二萜的首例。化合物 1 没有细胞毒性，但能抑制 17-β-雌二醇诱导的细胞增殖（IC = 11.42 ± 0.85 μM）。
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