Li Qin, Fu Aimin, Dong Jiaxin, Xiao Yang, Dai Bingbing, Wei Mengsha, Huang Zijian, Liu Junjun, Chen Chunmei, Zhu Hucheng, Lu Yuanyuan, Li Dongyan, Zhang Yonghui
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Department of Pharmacy, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Fitoterapia. 2024 Mar;173:105790. doi: 10.1016/j.fitote.2023.105790. Epub 2023 Dec 27.
Three new furano-lactones, asperilactones A-C (1-3), and two known compounds silvaticol (4) and violaceic acid (5) were isolated from an ethanol extract of Aspergillus nidulans, a fungus isolated from the Annelida Whitmania pigra Whitman (Haemopidae). Their structures were elucidated by a combination of spectroscopy, ECD calculations, comparing optical rotation values, and single-crystal X-ray diffraction analyses. Asperilactone A (1) represented the first example of furano-lactone with an unusual 2-thia-6-oxabicyclo[3.3.0]octane ring system. Asperilactones A and B showed weak toxicity against the HL-60 and RKO.
从采自环节动物宽体金线蛭（金线蛭科）的真菌构巢曲霉的乙醇提取物中分离出三种新的呋喃内酯，即曲霉内酯A-C（1-3），以及两种已知化合物林地酚（4）和紫草酸（5）。通过光谱学、ECD计算、比较旋光值和单晶X射线衍射分析相结合的方法阐明了它们的结构。曲霉内酯A（1）是具有不寻常的2-硫杂-6-氧杂双环[3.3.0]辛烷环系的呋喃内酯的首个实例。曲霉内酯A和B对HL-60和RKO显示出弱毒性。
