asperterpenols A 和 B，从红树林内生真菌 Aspergillus sp. 085242 中分离得到的新甾体化合物。
Asperterpenols A and B, new sesterterpenoids isolated from a mangrove endophytic fungus Aspergillus sp. 085242.
机构信息
School of Chemistry and Chemical Engineering and School of Life Sciences, Sun Yat-sen University , Guangzhou 510275, China, and School of Chemistry and Environment, South China Normal University , 348 West Outer Ring Road, Guangzhou 510006, China.
出版信息
Org Lett. 2013 May 17;15(10):2522-5. doi: 10.1021/ol401005j. Epub 2013 May 3.
Asperterpenol A (1) and asperterpenol B (2), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus Aspergillus sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 inhibit acetylcholinesterase with IC50 values of 2.3 and 3.0 μM, respectively.
asperterpenol A（1）和 asperterpenol B（2），两种新型的倍半萜类化合物，具有不寻常的 5/8/6/6 四环骨架，从红树林内生真菌 Aspergillus sp. 085242 中分离得到。结构是根据光谱方法阐明的，绝对构型是通过单晶 X 射线衍射分析确定的。化合物 1 和 2 对乙酰胆碱酯酶的抑制作用分别为 2.3 和 3.0 μM。
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