Charles Perkins Centre, Camperdown, New South Wales, Australia.
Programa de Pós-Graduação em Ecologia e Conservação, Federal University of Paraná, Curitiba, Brazil.
PLoS One. 2019 Mar 13;14(3):e0212796. doi: 10.1371/journal.pone.0212796. eCollection 2019.
While there is a burgeoning interest in the effects of nutrition on systemic inflammatory diseases, how dietary macronutrient balance impacts local chronic inflammatory diseases in the mouth has been largely overlooked. Here, we used the Geometric Framework for Nutrition to test how the amounts of dietary macronutrients and their interactions, as well as carbohydrate type (starch vs sucrose vs resistant starch) influenced periodontitis-associated alveolar bone height in mice. Increasing intake of carbohydrates reduced alveolar bone height, while dietary protein had no effect. Whether carbohydrate came from sugar or starch did not influence the extent of alveolar bone height. In summary, the amount of carbohydrate in the diet modulated periodontitis-associated alveolar bone height independent of the source of carbohydrates.
虽然人们对营养对系统性炎症性疾病的影响越来越感兴趣，但饮食中宏量营养素的平衡如何影响口腔局部慢性炎症性疾病在很大程度上被忽视了。在这里，我们使用营养的几何框架来测试饮食中宏量营养素的量及其相互作用，以及碳水化合物的类型（淀粉与蔗糖与抗性淀粉）如何影响小鼠的牙周炎相关牙槽骨高度。增加碳水化合物的摄入会降低牙槽骨高度，而饮食中的蛋白质则没有影响。碳水化合物来自糖还是淀粉并不影响牙槽骨高度的程度。总之，饮食中碳水化合物的量调节了牙周炎相关的牙槽骨高度，而与碳水化合物的来源无关。
