Yeung Edwina H, Kim Keewan, Purdue-Smithe Alexandra, Bell Griffith, Zolton Jessica, Ghassabian Akhgar, Vafai Yassaman, Robinson Sonia L, Mumford Sunni L
Department of Pediatrics, New York University School of Medicine, New York.
Department of Environmental Medicine, New York University School of Medicine, New York, New York.
Semin Reprod Med. 2018 May;36(3-04):183-194. doi: 10.1055/s-0038-1675778. Epub 2019 Mar 13.
Concerns remain about the health of children conceived by infertility treatment. Studies to date have predominantly not identified substantial long-term health effects after accounting for plurality, which is reassuring given the increasing numbers of children conceived by infertility treatment worldwide. However, as technological advances in treatment arise, ongoing studies remain critical for monitoring health effects. To study whether the techniques used in infertility treatment cause health differences, however, remains challenging due to identification of an appropriate comparison group, heterogeneous treatment, and confounding by the underlying causes of infertility. In fact, the factors that are associated with underlying infertility, including parental obesity and other specific male and female factors, may be important independent factors to consider. This review will summarize key methodological considerations in studying children conceived by infertility treatment including the evidence of associations between underlying infertility factors and child health.
对于通过不孕治疗受孕的儿童的健康状况，人们仍然存在担忧。迄今为止的研究在考虑多胎因素后，大多未发现重大的长期健康影响，鉴于全球通过不孕治疗受孕的儿童数量不断增加，这令人安心。然而，随着治疗技术的进步，持续进行的研究对于监测健康影响仍然至关重要。然而，由于确定合适的对照组、治疗方法的异质性以及不孕潜在原因的混杂作用，研究不孕治疗中使用的技术是否会导致健康差异仍然具有挑战性。事实上，与潜在不孕相关的因素，包括父母肥胖以及其他特定的男性和女性因素，可能是需要考虑的重要独立因素。本综述将总结研究通过不孕治疗受孕儿童的关键方法学考量，包括潜在不孕因素与儿童健康之间关联的证据。
