Ibrahim Yetunde, Hotaling Jim
Department of Obstetrics and Gynecology, Utah Center for Reproductive Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah.
Semin Reprod Med. 2018 May;36(3-04):233-239. doi: 10.1055/s-0038-1677047. Epub 2019 Mar 13.
Sperm epigenetic programming is tailored to meet the need of this specialized cell, which include its interaction with the oocyte during fertilization and early embryo development. The unique nature of the sperm epigenome has resulted in multiple studies investigating how perturbations in epigenetics might impact male fertility and early embryo development. In addition, sperm epigenetics appear to be altered by specific environmental exposures, which could provide a link for investigating the role of these triggers in somatic health of off springs produced. This has the potential of explaining otherwise missing heritability factors seen with several diseases. While this field of investigation is new and with limited validation, it is intriguing and further studies are warranted.
精子表观遗传编程是为满足这种特殊细胞的需求而量身定制的，这些需求包括其在受精和早期胚胎发育过程中与卵母细胞的相互作用。精子表观基因组的独特性质引发了多项研究，旨在探究表观遗传学的扰动如何影响男性生育能力和早期胚胎发育。此外，精子表观遗传学似乎会因特定的环境暴露而改变，这可能为研究这些触发因素在后代体细胞健康中的作用提供一个联系。这有可能解释一些疾病中出现的其他无法解释的遗传因素。虽然这个研究领域尚新且验证有限，但它很有趣，值得进一步研究。
