Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
Institute for Macromolecular Chemistry, Albert-Ludwigs-University Freiburg, Stefan-Meier-Strasse 31, 79104, Freiburg, Germany.
Angew Chem Int Ed Engl. 2019 May 27;58(22):7335-7340. doi: 10.1002/anie.201901880. Epub 2019 Apr 17.
Recent years have seen an increased interest in the use of ABC triblock terpolymers to bottom-up assemble multicompartment patchy nanoparticles. Despite these experimental and theoretical efforts, the applications of polymer-based patchy nanoparticles remain rather limited. One of the major challenges that eclipses their potential is the lack of knowledge to selectively encapsulate cargoes within different compartments that are separated in the nanometer length scale. Here, strategies are reported to segregate two chemically distinct molecules in either the patches or core compartment of patchy nanoparticles that bear a (bioactive) sugar corona. The potential use of these bioactive patchy nanoparticles containing compartmentalized cargoes for simultaneous drug delivery with real-time release monitoring capabilities is further demonstrated.
近年来，人们越来越感兴趣地使用 ABC 三嵌段共聚物自下而上组装多隔室有缺陷纳米粒子。尽管进行了这些实验和理论研究，但基于聚合物的有缺陷纳米粒子的应用仍然相当有限。阻碍其潜力发挥的主要挑战之一是缺乏选择性地将货物封装在纳米尺度上分离的不同隔室中的知识。在这里，报道了在带有（生物活性）糖冠的有缺陷纳米粒子的胶块或核隔室中分离两种化学性质不同的分子的策略。进一步证明了这些含有隔室货物的生物活性有缺陷纳米粒子在实时释放监测能力下同时进行药物递送的潜在用途。
