Department of Family Medicine, Pusan National University School of Medicine, Busandaehak-ro, Mulgeum-eup, Yangsan-si 50612, Korea.
Biomedical Research Institute, Pusan National University Hospital, Busan 602-739, Korea.
Mar Drugs. 2019 Mar 7;17(3):157. doi: 10.3390/md17030157.
Recent animal studies found the potential of a collagen peptide derived from skate skin to have anti-obesity effects through the suppression of fat accumulation and regulation of lipid metabolism. However, no studies have yet been performed in humans. Here, this very first human randomized, placebo-controlled, and double-blinded study was designed to investigate the efficacy and tolerability of skate skin collagen peptides (SCP) for the reduction of body fat in overweight adults. Ninety healthy volunteers (17 men) aged 41.2 ± 10.4 years with a mean body mass index of 25.6 ± 1.9 kg/m² were assigned to the intervention group (IG), which received 2000 mg of SCP per day or to the control group (CG) given the placebo for 12 weeks and 81 (90%) participants completed the study. Changes in body fat were evaluated using dual energy X-ray absorptiometry as a primary efficacy endpoint. After 12 weeks of the trial, the percentage of body fat and body fat mass (kg) in IG were found to be significantly better than those of subjects in CG (-1.2% vs. 2.7%, = 0.024 and -1.2 kg vs. 0.3 kg, = 0.025). Application of SCP was well tolerated and no notable adverse effect was reported from both groups. These results suggest the beneficial potential of SCP in the reduction of body fat in overweight adults.
最近的动物研究发现，源自软骨鱼皮的胶原蛋白肽通过抑制脂肪堆积和调节脂质代谢，具有抗肥胖作用。然而，目前尚未在人体中进行相关研究。本研究首次设计了一项随机、安慰剂对照、双盲临床试验，旨在探究口服胶原蛋白肽（SCP）对超重成年人降低体脂的有效性和耐受性。90 名健康志愿者（17 名男性），年龄 41.2±10.4 岁，平均 BMI 为 25.6±1.9kg/m²，被随机分为干预组（IG），每天摄入 2000mg 的 SCP，或安慰剂组（CG），共干预 12 周。采用双能 X 射线吸收法（DXA）评估体脂变化，作为主要疗效终点。试验 12 周后，IG 组的体脂百分比和体脂质量（kg）显著低于 CG 组（-1.2% vs. 2.7%， = 0.024 和-1.2kg vs. 0.3kg， = 0.025）。SCP 应用具有良好的耐受性，两组均未报告明显的不良反应。这些结果提示 SCP 可能具有降低超重成年人体脂的作用。
