NLRC5：免疫和炎症反应中 NLRs 的典范。
NLRC5: A paradigm for NLRs in immunological and inflammatory reaction.
机构信息
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, PR China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education, Hefei, Anhui, 230032, PR China.
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, PR China.
出版信息
Cancer Lett. 2019 Jun 1;451:92-99. doi: 10.1016/j.canlet.2019.03.005. Epub 2019 Mar 10.
The nucleotide-binding domain leucine-rich repeat containing (NLR) family of proteins is mainly involved in microbial pathogen recognition, inflammatory responses, and cell death. NLRC5, the largest member of the NLR family, is currently receiving an increasing level of attention. NLRC5 has been demonstrated to be a potent negative regulator of NF-κB signaling pathway-mediated inflammatory response. Moreover, accumulating evidence has indicated that NLRC5 is closely related to pathological processes of various cancers. In this review, we present an overview on NLRC5, addressing its underlying molecular mechanisms and implications in host defense, inflammatory response, and associated cancers.
核苷酸结合域富含亮氨酸重复蛋白（NLR）家族主要参与微生物病原体识别、炎症反应和细胞死亡。NLRC5 是 NLR 家族中最大的成员，目前受到越来越多的关注。NLRC5 已被证明是 NF-κB 信号通路介导的炎症反应的有效负调节剂。此外，越来越多的证据表明 NLRC5 与各种癌症的病理过程密切相关。在这篇综述中，我们概述了 NLRC5，阐述了其在宿主防御、炎症反应和相关癌症中的潜在分子机制和意义。
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