口服药物中的“赋形剂”。
"Inactive" ingredients in oral medications.
机构信息
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Sci Transl Med. 2019 Mar 13;11(483). doi: 10.1126/scitranslmed.aau6753.
Abstract
Oral forms of medications contain "inactive" ingredients to enhance their physical properties. Using data analytics, we characterized the abundance and complexity of inactive ingredients in approved medications. A majority of medications contain ingredients that could cause adverse reactions, underscoring the need to maximize the tolerability and safety of medications and their inactive ingredients.
摘要
口服药物制剂含有“赋形剂”以改善其物理性质。我们采用数据分析方法对已批准药物中赋形剂的含量和复杂性进行了特征分析。大多数药物含有可能引起不良反应的成分，这突出表明需要最大限度地提高药物及其赋形剂的耐受性和安全性。
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