肿瘤免疫的宿主组织决定因素。
Host tissue determinants of tumour immunity.
机构信息
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Precision Immunology Institute and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
出版信息
Nat Rev Cancer. 2019 Apr;19(4):215-227. doi: 10.1038/s41568-019-0125-9.
Abstract
Although common evolutionary principles drive the growth of cancer cells regardless of the tissue of origin, the microenvironment in which tumours arise substantially differs across various organ sites. Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driven by tissue environmental factors. In this Review, we discuss how tissue-specific determinants might influence tumour development and argue that unravelling the tissue-specific contribution to tumour immunity should help the development of precise immunotherapeutic strategies for patients with cancer.
摘要
尽管常见的进化原则推动了癌细胞的生长，而与肿瘤起源的组织无关，但肿瘤发生的微环境在不同的器官部位有很大的不同。最近的研究已经确定，除了细胞内在的影响外，肿瘤生长的调节还取决于组织环境因素驱动的局部线索。在这篇综述中，我们讨论了组织特异性决定因素如何影响肿瘤的发展，并认为阐明肿瘤免疫的组织特异性贡献应该有助于为癌症患者开发精确的免疫治疗策略。
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