Awada Hassan, Kewan Tariq, Covut Fahrettin, Daw Hamed, Haddad Abdo
Internal Medicine, Cleveland Clinic - Fairview Hospital, Cleveland, USA.
Hematology and Oncology, Cleveland Clinic - Fairview Hospital, Cleveland, USA.
Cureus. 2019 Jan 3;11(1):e3822. doi: 10.7759/cureus.3822.
Waldenström's macroglobulinemia (WM) and multiple myeloma (MM) are two distinct forms of mature hematologic B-cell malignancies. A missense somatic mutation in MYD88 gene (MYD88L265P) has been found in hematologic B-cell malignancies. The simultaneous presentation of Waldenström's macroglobulinemia and MYD88 mutation with multiple myeloma in the same patient is very rare and only a few cases have been reported in the literature.
华氏巨球蛋白血症（WM）和多发性骨髓瘤（MM）是成熟血液B细胞恶性肿瘤的两种不同形式。在血液B细胞恶性肿瘤中发现了MYD88基因的错义体细胞突变（MYD88L265P）。同一患者同时出现华氏巨球蛋白血症和MYD88突变以及多发性骨髓瘤的情况非常罕见，文献中仅报道了少数病例。
