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由非手性三肽自组装形成的纳米球和纳米纤维的同时出现。

Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides.

作者信息

Vardhishna Malapaka Venkata, Srinivasulu Gannoju, Harikrishna Adicherl, Thakur Suman Siddharth, Chatterjee Bhaswati

机构信息

National Institute of Pharmaceutical Education and Research (NIPER) NIPER-Hyderabad Dept. of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India Balanagar Hyderabad - 500 037, Telangana India.

Proteomics and Cell Signaling, Lab E409 Centre for Cellular and Molecular Biology Uppal Road Hyderabad - 500007 India.

出版信息

ChemistryOpen. 2019 Jan 15;8(3):266-270. doi: 10.1002/open.201800258. eCollection 2019 Mar.

DOI:10.1002/open.201800258
PMID:30868048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6398100/
Abstract

The achiral tripeptide Boc-Aib-MABA-Aib-OMe has the ability to co-exist as nanospheres and as a network of nanofibers in methanol. Furthermore, AFM and TEM images show the presence of bulges in the network of nanofibers. Interestingly, the formation of nanofibers is seen to emerge from the outer boundary of the spherical structures. Some of the nanofibers curl up at the tip and later result in the formation of hollow nanospheres with thick boundaries. The presence of β-turn-like structures with hydrogen bonding is observed using FT-IR studies. The presence of hydrogen bonding is also demonstrated by using NMR studies.

摘要

非手性三肽Boc-Aib-MABA-Aib-OMe在甲醇中能够以纳米球和纳米纤维网络的形式共存。此外，原子力显微镜（AFM）和透射电子显微镜（TEM）图像显示纳米纤维网络中存在凸起。有趣的是，纳米纤维的形成似乎是从球形结构的外边界开始的。一些纳米纤维在尖端卷曲，随后形成具有厚边界的中空纳米球。通过傅里叶变换红外光谱（FT-IR）研究观察到具有氢键的β-转角样结构的存在。核磁共振（NMR）研究也证明了氢键的存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/dad563ac6f6e/OPEN-8-266-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/2889d73d3707/OPEN-8-266-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/ad5eb2195348/OPEN-8-266-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/bc6f92fd8563/OPEN-8-266-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/8224da5e4144/OPEN-8-266-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/8d0db5a29490/OPEN-8-266-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/dad563ac6f6e/OPEN-8-266-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/2889d73d3707/OPEN-8-266-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/ad5eb2195348/OPEN-8-266-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/bc6f92fd8563/OPEN-8-266-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/8224da5e4144/OPEN-8-266-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/8d0db5a29490/OPEN-8-266-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da9d/6398100/dad563ac6f6e/OPEN-8-266-g006.jpg

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