二酮哌嗪凝胶：环二肽自组装的新视野。
Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides.
机构信息
Chemical and Pharmaceutical Sciences Department, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy.
National Interuniversity Consortium of Materials Science and Technology (INSTM), University of Trieste, 34127 Trieste, Italy.
出版信息
Molecules. 2021 Jun 3;26(11):3376. doi: 10.3390/molecules26113376.
Abstract
Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interest in a variety of fields spanning from functional materials to drug discovery. This concise review will analyze the latest advancements in their synthesis, self-assembly into gels, and their more innovative applications.
摘要
环二肽（CDPs）或 2,5-二酮哌嗪（DKPs）可发挥多种生物活性，并表现出相对于线性二肽类似物的显著抗酶解水解性和自组装成凝胶的倾向。它们在从功能材料到药物发现等多个领域引起了极大的兴趣。这篇简明的综述将分析它们在凝胶合成、自组装及其更具创新性应用方面的最新进展。
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