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High pressure liquid chromatographic determination of carbocisteine in human plasma and urine.

作者信息

Bron J

出版信息

Pharm Weekbl Sci. 1986 Apr 25;8(2):134-8. doi: 10.1007/BF02086147.

DOI:10.1007/BF02086147
PMID:3086832
Abstract

A method is described for the direct analysis of the amino acid carbocisteine in plasma and urine samples, following reaction with dabsyl chloride. Dabsylated carbocisteine is subjected to high pressure liquid chromatography with spectrophotometric detection at 425 nm. The usefulness of the method for bioavailability studies is discussed and compared with methods currently in use.

摘要

相似文献

1
High pressure liquid chromatographic determination of carbocisteine in human plasma and urine.
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引用本文的文献

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Bioanalytical Method for Carbocisteine in Human Plasma by Using LC-MS/MS: A Pharmacokinetic Application.采用液相色谱-串联质谱法测定人血浆中羧甲司坦的生物分析方法：药代动力学应用。
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Fluorimetric determination of some sulfur containing compounds through complex formation with terbium (Tb+3) and uranium (U+3).通过与铽（Tb³⁺）和铀（U³⁺）形成配合物对某些含硫化合物进行荧光测定。
J Fluoresc. 2007 May;17(3):293-300. doi: 10.1007/s10895-007-0172-6. Epub 2007 Apr 18.

本文引用的文献

1
Comparative bioavailability of S-carboxymethylcysteine from two dosage forms: hard gelatin capsule and syrup.两种剂型（硬明胶胶囊和糖浆）的S-羧甲基半胱氨酸的相对生物利用度。
Biopharm Drug Dispos. 1982 Jul-Sep;3(3):275-81. doi: 10.1002/bdd.2510030310.
2
Determination of urinary amino acids by liquid chromatography with "dabsyl chloride".
Clin Chem. 1980 Apr;26(5):579-83.
3
Ligand exchange amino acid analysis: resolution of some amino sugars and cysteine derivatives.
Anal Biochem. 1971 Jun;41(2):314-22. doi: 10.1016/0003-2697(71)90148-5.
4
[The bioavailability and pharmacokinetics of two carbocysteine preparations after single and multiple dosing].两种羧甲司坦制剂单次及多次给药后的生物利用度和药代动力学
Arzneimittelforschung. 1985;35(1):163-6.
5
Chromophoric labeling of amino acids with 4-dimethylaminoazobenzene-4'-sulfonyl chloride.用4-二甲基氨基偶氮苯-4'-磺酰氯对氨基酸进行发色团标记。
Anal Chem. 1975 Aug;47(9):1634-8. doi: 10.1021/ac60359a007.
6
Determination of carbocysteine from human plasma.人血浆中半胱氨酸的测定。
J Pharm Sci. 1978 Dec;67(12):1753-5. doi: 10.1002/jps.2600671232.
7
Identification of S-(carboxymethyl)-L-cysteine and thiodiglycolic acid, urinary metabolites of 2,2'-bis-(chloroethyl)-ether in the rat.大鼠体内2,2'-双（氯乙基）醚的尿液代谢产物S-（羧甲基）-L-半胱氨酸和硫代二甘醇酸的鉴定。
Cancer Lett. 1979 Sep;7(5):299-305. doi: 10.1016/s0304-3835(79)80057-9.
8
Excretion and biotransformation of carboxymethyl-cysteine in rat, dog, monkey and man.
Xenobiotica. 1978 Oct;8(10):621-8. doi: 10.3109/00498257809069574.