大鼠体内2,2'-双（氯乙基）醚的尿液代谢产物S-（羧甲基）-L-半胱氨酸和硫代二甘醇酸的鉴定。
Identification of S-(carboxymethyl)-L-cysteine and thiodiglycolic acid, urinary metabolites of 2,2'-bis-(chloroethyl)-ether in the rat.
作者信息
Müller G, Norpoth K, Eckard R
出版信息
Cancer Lett. 1979 Sep;7(5):299-305. doi: 10.1016/s0304-3835(79)80057-9.
PMID:509409
Abstract
S-(carboxymethyl)-L-cysteine (CMC) and thiodiglycollic acid (TGA) were identified by gas chromatographic-mass spectrometric measurements in the urine of rats after intraperitoneal injections of 2,2'-bis-(chloroethyl)-ether (BCEE). It is therefore probable that BCEE is O-dealkylated by a mixed-function oxidation. The hepatocarcinogenic effect of BCEE may be explained by the liberation of chloroacetaldehyde in vivo.
摘要
在给大鼠腹腔注射2,2'-双（氯乙基）醚（BCEE）后，通过气相色谱 - 质谱测量在大鼠尿液中鉴定出S-（羧甲基）-L-半胱氨酸（CMC）和硫代二甘醇酸（TGA）。因此，BCEE很可能通过混合功能氧化进行O-脱烷基化。BCEE的肝癌致癌作用可能是由于体内氯乙醛的释放所致。
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