Schrader B J, Bauman J L, Zeller F P, Shanes J G, Rich S
Pharmacotherapy. 1986 Mar-Apr;6(2):83-6. doi: 10.1002/j.1875-9114.1986.tb03457.x.
The acceptance, preference, and side effects of the 3 commercially available nitroglycerin patches were examined in 30 patients with chronic, stable angina pectoris. Patients were serially interviewed after each treatment period regarding patch comfort, aesthetics, discomfort upon removal, adhesiveness, efficacy, and side effects. They were also interviewed and examined for adverse skin reactions. There were significant differences among the 3 patches with respect to comfort, aesthetics, discomfort, and adhesiveness. Skin reactions (mostly mild) occurred in 83% of patients: patch A, 70%; patch B, 43%; and patch C, 57%. Intolerable reactions, which would have caused patch discontinuation, were noted in 40% of patients: patch A, 30%; patch B, 7%; and patch C, 10%. Most patients had an intolerable reaction to only 1 patch. Significant differences were present only between patches A and B with respect to total and intolerable skin reactions. Thus the systems differed in terms of patient preference and skin reactions. Skin reactions are probably more prevalent than previously reported but usually occur with just one of the patches. Physicians and hospitals should probably individualize nitrate patch therapy within formulary and budgetary constraints.
对30例慢性稳定性心绞痛患者使用的3种市售硝酸甘油贴片的接受程度、偏好及副作用进行了研究。在每个治疗周期结束后，对患者进行连续访谈，询问贴片的舒适度、美观度、取下时的不适感、粘性、疗效及副作用。还对患者进行访谈并检查有无皮肤不良反应。3种贴片在舒适度、美观度、不适感及粘性方面存在显著差异。83%的患者出现皮肤反应（大多为轻度）：贴片A为70%；贴片B为43%；贴片C为57%。40%的患者出现了可能导致停用贴片的难以忍受的反应：贴片A为30%；贴片B为7%；贴片C为10%。大多数患者仅对1种贴片有难以忍受的反应。仅在贴片A和贴片B之间，总的皮肤反应及难以忍受的皮肤反应存在显著差异。因此，不同系统在患者偏好和皮肤反应方面存在差异。皮肤反应可能比之前报道的更为普遍，但通常仅在其中一种贴片使用时出现。医生和医院可能应在处方集及预算限制范围内对硝酸盐贴片治疗进行个体化。
