Department of Biomedicine, Immunobiology, University of Basel, Basel, Switzerland.
Clin Exp Immunol. 2019 Aug;197(2):161-169. doi: 10.1111/cei.13291. Epub 2019 Mar 25.
Perception of potential threat is key for survival. The immune system constantly patrols the organism scanning for potential pathogenic or malignant danger. Recent evidence suggests that immunosurveillance not only relies on classic receptors [e.g. Toll-like receptors (TLRs) or antibodies] but is also based on sensing of the metabolic environment. Metabolites interact in numerous ways with immune cells, and are therefore more than just reaction intermediates. This new perspective opens the door for potential, future therapeutic strategies. Here we describe how immune functionality during infections, cancer or autoimmunity, as exemplified by short-chain fatty acids, lactate and reactive oxygen species (ROS), can be shaped by metabolic intermediates.
感知潜在威胁是生存的关键。免疫系统不断巡视机体，以发现潜在的致病或恶性危险。最近的证据表明，免疫监视不仅依赖于经典受体（例如 Toll 样受体 (TLR) 或抗体），而且还基于对代谢环境的感知。代谢物以多种方式与免疫细胞相互作用，因此它们不仅仅是反应中间体。这一新观点为潜在的未来治疗策略打开了大门。在这里，我们描述了代谢中间产物如何塑造感染、癌症或自身免疫过程中的免疫功能，例如短链脂肪酸、乳酸和活性氧 (ROS)。
