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肠道微生物群衍生的短链脂肪酸是肠道炎症的潜在介质。

Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation.

作者信息

Akhtar Muhammad, Chen Yan, Ma Ziyu, Zhang Xiaolong, Shi Deshi, Khan Jawaria A, Liu Huazhen

机构信息

Department of Basic Veterinary Medicine, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

Department of Preventive Veterinary Medicine, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.

出版信息

Anim Nutr. 2021 Dec 29;8:350-360. doi: 10.1016/j.aninu.2021.11.005. eCollection 2022 Mar.

DOI:10.1016/j.aninu.2021.11.005
PMID:35510031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9040132/
Abstract

Gut inflammation is a challenging concern in humans and animals, which disturbs normal growth and leads to severe bowel diseases. Short chain fatty acids (SCFA) are the gut microbiota metabolites produced from fermentation of non-digestible carbohydrates, and have been reported to modulate gut inflammation. SCFA have been implicated as the potential therapeutic bioactive molecules for gut inflammatory diseases, and could be an alternative to antibiotic growth promoters (AGP). In this review, the existing knowledge about the types of SCFA, the related gut microbes producing SCFA, the roles of SCFA in maintaining gut homeostasis, and how SCFA modulate gut inflammation is summarized. The therapeutic application of SCFA in the treatment of inflammatory bowel disease (IBD) is also highlighted.

摘要

肠道炎症是人类和动物面临的一个具有挑战性的问题，它会干扰正常生长并导致严重的肠道疾病。短链脂肪酸（SCFA）是由不可消化碳水化合物发酵产生的肠道微生物群代谢产物，据报道可调节肠道炎症。SCFA被认为是肠道炎症性疾病的潜在治疗性生物活性分子，并且可能成为抗生素生长促进剂（AGP）的替代品。在这篇综述中，总结了关于SCFA的类型、产生SCFA的相关肠道微生物、SCFA在维持肠道稳态中的作用以及SCFA如何调节肠道炎症的现有知识。还强调了SCFA在治疗炎症性肠病（IBD）中的治疗应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/c8ae4f4677e8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/0c538be79212/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/dc4da903dd1b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/d3bd253d626c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/f2d2e31f8fe9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/7dfda97519f0/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/7c0b3b32e84c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/c8ae4f4677e8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/0c538be79212/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/dc4da903dd1b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/d3bd253d626c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/f2d2e31f8fe9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/7dfda97519f0/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/7c0b3b32e84c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50b5/9040132/c8ae4f4677e8/gr6.jpg

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本文引用的文献

[1]
Recent advances in the therapeutic application of short-chain fatty acids (SCFAs): An updated review.

Crit Rev Food Sci Nutr. 2022

[2]
The lung-gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes.

Mucosal Immunol. 2021-3

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The Combinatorial Effect of Acetate and Propionate on High-Fat Diet Induced Diabetic Inflammation or Metaflammation and T Cell Polarization.

Inflammation. 2021-2

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Gut microbial metabolites as multi-kingdom intermediates.

Nat Rev Microbiol. 2021-2

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The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells.

Exp Mol Med. 2020-9

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Gut microbiota in human metabolic health and disease.

Nat Rev Microbiol. 2021-1

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Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function.

Nat Metab. 2020-9

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Nutrients. 2020-4-16

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World J Gastroenterol. 2020-3-28

[10]
Intestinal inflammation induced by dextran sodium sulphate causes liver inflammation and lipid metabolism disfunction in laying hens.

Poult Sci. 2020-1-22

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