小鼠q、k、u、s和f单倍型I-Aβ cDNA克隆的序列分析及结构-功能相关性
Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones.
作者信息
Estess P, Begovich A B, Koo M, Jones P P, McDevitt H O
出版信息
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3594-8. doi: 10.1073/pnas.83.11.3594.
Abstract
I-A beta-chain cDNA clones from mice of the q, k, u, s, and f haplotypes have been isolated and sequenced. Nucleotide sequence comparisons among these five A beta chains show considerable allelic variation in the region encoding the first external (beta 1) domain of the mature A beta protein. The beta 1 domain variability is clustered into three discrete regions, two of which divide the A beta chains into subgroups, suggesting an evolutionary history for the separation of alleles in inbred strains of mice. The amino acid sequences of these five chains are compared to each other and to previously published I-A beta chains. Correlations are made between the primary structural differences and the serologic and immune response characteristics mapping to the I-A subregion.
摘要
已分离并测序了来自q、k、u、s和f单倍型小鼠的I-Aβ链cDNA克隆。这五条Aβ链之间的核苷酸序列比较显示，在成熟Aβ蛋白的第一个外部（β1）结构域编码区域存在相当大的等位基因变异。β1结构域的变异性集中在三个离散区域，其中两个区域将Aβ链分为亚组，这表明在近交系小鼠中，等位基因分离具有进化史。将这五条链的氨基酸序列相互比较，并与先前发表的I-Aβ链进行比较。对一级结构差异与映射到I-A亚区域的血清学和免疫反应特征之间进行了相关性分析。
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