Mengle-Gaw L, McDevitt H O
Proc Natl Acad Sci U S A. 1985 May;82(9):2910-4. doi: 10.1073/pnas.82.9.2910.
Ia antigens are polymorphic cell-surface glycoprotein complexes, encoded within the I region of the mouse major histocompatibility complex, that control the ability of the organism to mount effective antigen-specific immune responses. We have isolated and determined the nucleotide sequences of cDNA and genomic clones for the I-E beta s gene and we present the predicted protein sequence for most of the E beta s polypeptide chain. The E beta s polypeptide shows 95% protein homology to the other cloned E beta alleles. Comparison of the protein sequences of five E beta alleles from haplotypes that differ in responder phenotype to pigeon cytochrome c suggests that the structure of one of the E beta hypervariable regions may determine responsiveness to this antigen.
Ia抗原是多态性细胞表面糖蛋白复合物,由小鼠主要组织相容性复合体的I区域编码,控制机体产生有效的抗原特异性免疫反应的能力。我们已经分离并确定了I-Eβs基因的cDNA和基因组克隆的核苷酸序列,并给出了大部分Eβs多肽链的预测蛋白质序列。Eβs多肽与其他克隆的Eβ等位基因显示出95%的蛋白质同源性。对来自对鸽细胞色素c反应表型不同的单倍型的五个Eβ等位基因的蛋白质序列进行比较表明,Eβ高变区之一的结构可能决定对该抗原的反应性。