从小鼠I-E-β S-多肽链的cDNA和基因组克隆预测的蛋白质序列。
Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones.
作者信息
Mengle-Gaw L, McDevitt H O
出版信息
Proc Natl Acad Sci U S A. 1985 May;82(9):2910-4. doi: 10.1073/pnas.82.9.2910.
Abstract
Ia antigens are polymorphic cell-surface glycoprotein complexes, encoded within the I region of the mouse major histocompatibility complex, that control the ability of the organism to mount effective antigen-specific immune responses. We have isolated and determined the nucleotide sequences of cDNA and genomic clones for the I-E beta s gene and we present the predicted protein sequence for most of the E beta s polypeptide chain. The E beta s polypeptide shows 95% protein homology to the other cloned E beta alleles. Comparison of the protein sequences of five E beta alleles from haplotypes that differ in responder phenotype to pigeon cytochrome c suggests that the structure of one of the E beta hypervariable regions may determine responsiveness to this antigen.
摘要
Ia抗原是多态性细胞表面糖蛋白复合物，由小鼠主要组织相容性复合体的I区域编码，控制机体产生有效的抗原特异性免疫反应的能力。我们已经分离并确定了I-Eβs基因的cDNA和基因组克隆的核苷酸序列，并给出了大部分Eβs多肽链的预测蛋白质序列。Eβs多肽与其他克隆的Eβ等位基因显示出95%的蛋白质同源性。对来自对鸽细胞色素c反应表型不同的单倍型的五个Eβ等位基因的蛋白质序列进行比较表明，Eβ高变区之一的结构可能决定对该抗原的反应性。
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