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澳大利亚老年护理居民的皮肤和软组织感染及当前抗菌药物处方实践。

Skin and soft tissue infections and current antimicrobial prescribing practices in Australian aged care residents.

机构信息

National Centre for Antimicrobial Stewardship,792 Elizabeth St, Melbourne, Vic. 3000,Australia.

Victorian Healthcare Associated Infection Surveillance System Co-ordinating Centre,792 Elizabeth St, Melbourne, Vic. 3000,Australia.

出版信息

Epidemiol Infect. 2019 Jan;147:e87. doi: 10.1017/S0950268819000128.

DOI:10.1017/S0950268819000128
PMID:30869059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6519684/
Abstract

To determine the burden of skin and soft tissue infections (SSTI), the nature of antimicrobial prescribing and factors contributing to inappropriate prescribing for SSTIs in Australian aged care facilities, SSTI and antimicrobial prescribing data were collected via a standardised national survey. The proportion of residents prescribed ⩾1 antimicrobial for presumed SSTI and the proportion whose infections met McGeer et al. surveillance definitions were determined. Antimicrobial choice was compared to national prescribing guidelines and prescription duration analysed using a negative binomial mixed-effects regression model. Of 12 319 surveyed residents, 452 (3.7%) were prescribed an antimicrobial for a SSTI and 29% of these residents had confirmed infection. Topical clotrimazole was most frequently prescribed, often for unspecified indications. Where an indication was documented, antimicrobial choice was generally aligned with recommendations. Duration of prescribing (in days) was associated with use of an agent for prophylaxis (rate ratio (RR) 1.63, 95% confidence interval (CI) 1.08-2.52), PRN orders (RR 2.10, 95% CI 1.42-3.11) and prescription of a topical agent (RR 1.47, 95% CI 1.08-2.02), while documentation of a review or stop date was associated with reduced duration of prescribing (RR 0.33, 95% CI 0.25-0.43). Antimicrobial prescribing for SSTI is frequent in aged care facilities in Australia. Methods to enhance appropriate prescribing, including clinician documentation, are required.

摘要

为了确定皮肤和软组织感染(SSTI)的负担、抗菌药物处方的性质以及导致澳大利亚老年护理机构 SSTI 处方不当的因素,通过标准化的全国性调查收集了 SSTI 和抗菌药物处方数据。确定了因疑似 SSTI 而被处方 ⩾1 种抗菌药物的居民比例,以及符合 McGeer 等人监测定义的感染比例。比较了抗菌药物的选择与国家处方指南,并使用负二项式混合效应回归模型分析了处方持续时间。在接受调查的 12319 名居民中,有 452 名(3.7%)因 SSTI 而被处方抗菌药物,其中 29%的居民有确诊感染。最常开的是局部克霉唑,通常用于未指明的适应症。如果记录了适应症,则抗菌药物的选择通常与建议一致。(天)的处方持续时间与预防使用的药物有关(比值比(RR)1.63,95%置信区间(CI)1.08-2.52)、PRN 医嘱(RR 2.10,95%CI 1.42-3.11)和局部药物处方(RR 1.47,95%CI 1.08-2.02),而记录审查或停药日期与处方持续时间缩短有关(RR 0.33,95%CI 0.25-0.43)。在澳大利亚的老年护理机构中,SSTI 的抗菌药物处方很常见。需要采取措施提高适当的处方,包括临床医生的记录。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc14/6519684/9e3d12d6c9a1/S0950268819000128_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc14/6519684/9e3d12d6c9a1/S0950268819000128_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc14/6519684/9e3d12d6c9a1/S0950268819000128_fig1.jpg

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