噬菌体与抗生素联合成功治疗耐抗生素的多微生物骨感染
Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection With Bacteriophages and Antibiotics Combination.
作者信息
Nir-Paz Ran, Gelman Daniel, Khouri Ayman, Sisson Brittany M, Fackler Joseph, Alkalay-Oren Sivan, Khalifa Leron, Rimon Amit, Yerushalmy Ortal, Bader Reem, Amit Sharon, Coppenhagen-Glazer Shunit, Henry Matthew, Quinones Javier, Malagon Francisco, Biswas Biswajit, Moses Allon E, Merril Greg, Schooley Robert T, Brownstein Michael J, Weil Yoram A, Hazan Ronen
机构信息
Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University, Jerusalem, Israel.
出版信息
Clin Infect Dis. 2019 Nov 13;69(11):2015-2018. doi: 10.1093/cid/ciz222.
A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.
一名患有与广泛耐药鲍曼不动杆菌和多重耐药肺炎克雷伯菌相关的创伤性左胫骨感染的患者接受了噬菌体和抗生素治疗。组织迅速愈合，培养结果转阴。结果，患者的腿部无需截肢，目前正在接受康复治疗。
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