Abbas M, Srivastava K, Imran M, Banerjee M
a Molecular and Human Genetics Laboratory, Department of Zoology , University of Lucknow , Lucknow , India.
b Department of Microbiology , ERA University , Lucknow , India.
Br J Biomed Sci. 2019 Jul;76(3):117-121. doi: 10.1080/09674845.2019.1592884. Epub 2019 May 8.
: Carcinoma of cervix is the second most common cancer among women worldwide. The DNA repair network plays an important role in the maintenance of genetic stability, protection against DNA damage and carcinogenesis. Alterations in repair genes and and been reported in certain cancers. We hypothesised an association between +399A/G, +31467G/A and +18067C/T polymorphisms and the risk of cervical cancer. : This study included 525 subjects (265 controls and 260 cervical cancer cases). Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). : Women with GA and AA genotypes of +399A/G showed 2.4-3.8 fold higher risk of cervical cancer ( = 0.001). The +399A* allele was significantly linked with cervical cancer ( = 0.002). However, +31479G/A and +18067C/T polymorphisms did not show any statistically significant associations. : The +399A/G SNP is linked with cervical cancer. We suggest that this variant can be utilized as a prognostic marker for determination of cervical cancer susceptibility.
宫颈癌是全球女性中第二常见的癌症。DNA修复网络在维持基因稳定性、抵御DNA损伤和致癌过程中发挥着重要作用。在某些癌症中已报道了修复基因的改变。我们推测+399A/G、+31467G/A和+18067C/T多态性与宫颈癌风险之间存在关联。
本研究纳入了525名受试者（265名对照和260例宫颈癌病例）。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）确定基因型。
+399A/G的GA和AA基因型女性患宫颈癌的风险高2.4至3.8倍（P = 0.001）。+399A*等位基因与宫颈癌显著相关（P = 0.002）。然而，+31479G/A和+18067C/T多态性未显示任何统计学上的显著关联。
+399A/G单核苷酸多态性与宫颈癌相关。我们建议该变异可作为预测宫颈癌易感性的预后标志物。
