Department of Psychology, Dalian Medical University, Dalian, China.
Department of Neurology and Psychiatry, First Affiliated Hospital, Dalian Medical University, Dalian, China.
J Affect Disord. 2019 May 1;250:204-209. doi: 10.1016/j.jad.2019.03.019. Epub 2019 Mar 5.
Hypervigilance to panic-related stimuli is believed to play a critical role in the pathogenesis of panic disorder. The current event-related potential study explored whether this hyperresponsivity occurred in the absence of focused attention.
Mismatch negativity (MMN) responses to panic-related vs. neutral deviants were assessed in 15 medication-free panic patients without agoraphobia and 16 healthy controls using a reverse-standard-deviant paradigm.
Panic patients relative to healthy controls exhibited an enhanced MMN in response to panic-related sounds but a reduced MMN in response to neutral sounds. Furthermore, MMN responses were delayed in panic patients compared to healthy controls, irrespective of stimulus type.
The sample size is relatively small.
Our data provide evidence that panic disorder was associated with an increased sensitivity to panic-related changes, accompanied by a reduced sensitivity to other acoustic changes as well as a general slow-down of cognitive processing during the preattentive processing stage.
警觉过度是惊恐障碍发病机制中的关键因素。本事件相关电位研究旨在探究在缺乏集中注意力的情况下是否存在这种过度反应。
使用反转标准偏差范式，评估 15 名无恐惧症的药物治疗的惊恐障碍患者和 16 名健康对照者对惊恐相关与中性偏差的差异负波（MMN）反应。
与健康对照组相比，惊恐障碍患者对惊恐相关声音表现出增强的 MMN 反应，而对中性声音的 MMN 反应减弱。此外，无论刺激类型如何，与健康对照组相比，惊恐障碍患者的 MMN 反应均延迟。
样本量相对较小。
本研究结果表明，惊恐障碍患者对惊恐相关变化的敏感性增加，对其他声音变化的敏感性降低，以及在非注意加工阶段认知加工普遍减慢。
