基因多态性与突发性感音神经性听力损失易感性：一项系统综述。
Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review.
作者信息
Cao Zaizai, Gao Jinjian, Huang Saiyu, Xiang Haijie, Zhang Chuqin, Zheng Bo, Zhan Xiang, Chen Ruru, Chen Bobei
机构信息
Department of Otolaryngology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
The Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
出版信息
Audiol Neurootol. 2019;24(1):8-19. doi: 10.1159/000497032. Epub 2019 Mar 14.
BACKGROUND
Recently, genetic factors have been considered as an important risk factor for sudden sensorineural hearing loss (SSNHL). Many studies analyzed the association between SSNHL and polymorphisms. However, most of them gave inconclusive results. Key Message: We performed a systematic review to find out the association between polymorphisms and susceptibility to SSNHL. Finally, 47 studies involving 5,230 SSNHL patients and 68 genes were included for analysis and discussion of results. Polymorphisms in 26 genes have been suggested to be correlated with the susceptibility to SSNHL.
SUMMARY
Although a great number of studies support that polymorphisms in genes are associated with susceptibility to SSNHL, we need large multicenter studies, which evaluate multiple single nucleotide polymorphisms in SSNHL patients, to find real genetic risk factors for susceptibility to SSNHL. This is very helpful in designing more effective prevention and treatment strategies for patients with SSNHL.
背景
最近，遗传因素被认为是突发性感音神经性听力损失（SSNHL）的一个重要风险因素。许多研究分析了SSNHL与基因多态性之间的关联。然而，其中大多数研究结果并不确定。关键信息：我们进行了一项系统综述，以找出基因多态性与SSNHL易感性之间的关联。最终，纳入了47项涉及5230例SSNHL患者和68个基因的研究，用于分析和讨论结果。已表明26个基因中的多态性与SSNHL易感性相关。
总结
尽管大量研究支持基因多态性与SSNHL易感性相关，但我们需要大型多中心研究，对SSNHL患者的多个单核苷酸多态性进行评估，以找到SSNHL易感性的真正遗传风险因素。这对于为SSNHL患者设计更有效的预防和治疗策略非常有帮助。
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