白细胞介素-1 受体类型 1 和 2 基因多态性与台湾人群突发性聋的相关性：病例对照研究。
The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with sudden sensorineural hearing loss in a Taiwanese population: a case control study.
机构信息
Department of Otorhinolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Otorhinolaryngology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Kaohsiung, 807, Taiwan.
出版信息
J Otolaryngol Head Neck Surg. 2021 Dec 5;50(1):69. doi: 10.1186/s40463-021-00550-w.
BACKGROUND
Sudden sensorineural hearing loss (SSNHL) is a disease with an unknown etiology; damage to the auditory nerve from inflammation due to viral infection or vascular incidents has been implicated. According to several studies, cytokines, including interleukins, are associated with SSNHL in terms of serum expression and genetic polymorphisms. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with SSNHL. This study analyzed the association of single nucleotide polymorphisms (SNPs) of IL-1 receptor (IL-1R) genes with SSNHL in Taiwan.
METHODS
We conducted a case-control study involving 401 patients with SSNHL and 730 healthy controls. Four SNPs (IL-1R type 1 gene [IL1R1] [rs3917225 and rs2234650] and IL-1R type 2 gene [IL1R2] [rs4141134 and rs2071008]) were selected. The genotypes were determined using the TaqMan assay. The Hardy-Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated.
RESULTS
The TT genotype of rs2234650 had an adjusted odds ratio (OR) of 2.988 (95% confidence interval [95% CI] 1.27-6.82) (P = 0.012) compared with the CC genotype in patients with SSNHL. The SNP rs2234650 was associated with SSNHL in the recessive model (TT vs. CC + CT, P = 0.0206, OR = 2.681). The CT genotype of rs4141134 had an adjusted OR of 3.860 (95% CI 2.01-7.44; P < 0.0001) compared with the TT genotype, in patients with SSNHL. The SNP rs4141134 was associated with SSNHL under the dominant model (CC + CT vs. TT, P < 0.0001, OR = 4.087).
CONCLUSION
These findings suggest that IL1R1 and IL1R2 gene polymorphisms may contribute to an increased risk of SSNHL in Taiwan.
背景
突发性聋（SSNHL）是一种病因不明的疾病；炎症引起的听神经损伤与病毒感染或血管事件有关。根据几项研究，细胞因子（包括白细胞介素）与血清表达和遗传多态性有关。白细胞介素-1（IL-1）在炎症中起关键作用，可能与 SSNHL 有关。本研究分析了白细胞介素-1 受体（IL-1R）基因单核苷酸多态性（SNP）与台湾 SSNHL 的关系。
方法
我们进行了一项病例对照研究，纳入了 401 例 SSNHL 患者和 730 名健康对照者。选择了四个 SNP（IL-1R 型 1 基因 [IL1R1] [rs3917225 和 rs2234650] 和 IL-1R 型 2 基因 [IL1R2] [rs4141134 和 rs2071008]）。使用 TaqMan 法测定基因型。对每个 SNP 进行 Hardy-Weinberg 平衡（HWE）检验，并评估遗传效应。
结果
与 CC 基因型相比，SSNHL 患者 rs2234650 的 TT 基因型的校正优势比（OR）为 2.988（95%置信区间 [95%CI]1.27-6.82）（P=0.012）。在隐性模型中，SNP rs2234650 与 SSNHL 相关（TT 与 CC+CT，P=0.0206，OR=2.681）。与 TT 基因型相比，SSNHL 患者 rs4141134 的 CT 基因型的校正 OR 为 3.860（95% CI 2.01-7.44；P<0.0001）。在显性模型中，SNP rs4141134 与 SSNHL 相关（CC+CT 与 TT，P<0.0001，OR=4.087）。
结论
这些发现表明，白细胞介素-1 受体 1 和 2 基因多态性可能导致台湾 SSNHL 的风险增加。
Zotero 插件