突发性感音神经性听力损失中的基因多态性：最新进展
Genetic Polymorphisms in Sudden Sensorineural Hearing Loss: An Update.
作者信息
Corazzi Virginia, Ciorba Andrea, Bianchini Chiara, Pelucchi Stefano, Skarżyński Piotr Henryk, Hatzopoulos Stavros
机构信息
ENT & Audiology Department, 9299University Hospital of Ferrara, Ferrara, Italy.
49833Institute of Physiology and Pathology of Hearing, Warsaw, Poland.
出版信息
Ear Nose Throat J. 2021 Jun;100(3_suppl):337S-342S. doi: 10.1177/0145561320944657. Epub 2020 Aug 17.
OBJECTIVE
To investigate the association between genetic polymorphisms and sudden sensorineural hearing loss (SSNHL). Most of the SSNHL cases still remain idiopathic, and several etiopathogenetic hypotheses, including a genetic predisposition, have been proposed.
METHODS
A literature review was conducted using different databases: Medline/PubMed, EMBASE, and CINAHL, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All databases have been searched from May 2016 to April 2020.
RESULTS
Genetic susceptibility could represent a key element in the pathogenesis of SSNHL. A number of genetic polymorphisms related to (1) inner ear microvascular disease and endothelial dysfunction and (2) to inner ear oxidative stress and inflammation have been addressed in the current literature.
CONCLUSIONS
The potential identification of a genetic profile related to SSNHL could provide a more accurate prognostic evidence of idiopathic SSNHL (ISSNHL), offering to the patients not only early-prevention strategies but eventually information on various inheritance modalities.
目的
探讨基因多态性与突发性感音神经性听力损失（SSNHL）之间的关联。大多数SSNHL病例仍为特发性，并且已经提出了几种病因学假说，包括遗传易感性。
方法
根据系统评价和荟萃分析的首选报告项目指南，使用不同的数据库进行文献综述：医学在线数据库/医学期刊数据库（Medline/PubMed）、荷兰医学文摘数据库（EMBASE）和护理学与健康领域数据库（CINAHL）。所有数据库均于2016年5月至2020年4月期间进行检索。
结果
遗传易感性可能是SSNHL发病机制中的关键因素。有关（1）内耳微血管疾病和内皮功能障碍以及（2）内耳氧化应激和炎症的一些基因多态性在当前文献中已有论述。
结论
潜在的与SSNHL相关的基因图谱鉴定可为特发性SSNHL（ISSNHL）提供更准确的预后证据，不仅为患者提供早期预防策略，最终还能提供有关各种遗传方式的信息。
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