Obeng-Gyasi Emmanuel
Department of Built Environment, North Carolina Agricultural & Technical State University, Greensboro, NC 27411, USA.
Med Sci (Basel). 2019 Mar 12;7(3):42. doi: 10.3390/medsci7030042.
Lead exposure among pregnant U.S. women was examined via the National Health and Nutrition Examination Survey (NHANES) 2009⁻2016 data to examine its role in bad cholesterol and oxidative stress. Mean values of the clinical markers non-high density lipoprotein cholesterol (non-HDL-c) and gamma-glutamyl transferase (GGT), a marker of oxidative stress, were explored. In four quartiles of lead exposure, clinical makers were compared. Binary logistic regression predicted the likelihood of elevated clinical markers in pregnant compared to non-pregnant women, while linear regression was used to examine associations between blood lead levels (BLL) and the clinical markers of interest. Mean non-HDL-c was statistically significantly more elevated in pregnant women than non-pregnant women. Mean GGT levels were more statistically significantly elevated in the highest quartile of BLL exposure among pregnant women than in the lower quartiles. In binary logistic regression models, pregnant women were statistically significantly more likely to have elevated non-HDL-c, while in linear regression BLL was statistically significantly associated with GGT levels in pregnant women. Lead exposure in pregnant women is an issue of public health concern that must continue to be studied.
通过2009 - 2016年美国国家健康与营养检查调查（NHANES）的数据，对美国孕妇的铅暴露情况进行了研究，以考察其在不良胆固醇和氧化应激中的作用。探讨了临床指标非高密度脂蛋白胆固醇（non-HDL-c）和氧化应激标志物γ-谷氨酰转移酶（GGT）的平均值。在铅暴露的四个四分位数中，对临床指标进行了比较。二元逻辑回归预测了与未怀孕女性相比，怀孕女性临床指标升高的可能性，而线性回归则用于检验血铅水平（BLL）与相关临床指标之间的关联。孕妇的平均非高密度脂蛋白胆固醇水平在统计学上显著高于未怀孕女性。孕妇中血铅水平暴露最高四分位数组的平均GGT水平在统计学上比低四分位数组显著更高。在二元逻辑回归模型中，怀孕女性的非高密度脂蛋白胆固醇升高的可能性在统计学上显著更高，而在线性回归中，血铅水平与孕妇的GGT水平在统计学上显著相关。孕妇铅暴露是一个值得关注的公共卫生问题，必须继续进行研究。
